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Modulating immune responses with probiotic bacteria.

T Matsuzaki1, J Chin

  • 1Yakult Central Institute for Microbiological Research, Kunitachi-shi, Tokyo, Japan.

Immunology and Cell Biology
|January 29, 2000
PubMed
Summary
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Probiotic bacteria like Lactobacillus casei strain Shirota (LcS) can modulate immune responses, enhancing innate immunity and potentially treating allergies. Co-feeding probiotics with antigens can suppress immune responses, offering a strategy for autoimmune disease attenuation.

Area of Science:

  • Immunology
  • Microbiology
  • Gastroenterology

Background:

  • Probiotic bacteria are known for health benefits, potentially through immune modulation.
  • Lactobacillus casei strain Shirota (LcS) enhances innate immunity and influences T-helper cell responses.

Purpose of the Study:

  • To investigate the immunomodulatory effects of various probiotic bacteria.
  • To explore the potential of probiotics in managing allergic and autoimmune disorders.

Main Methods:

  • Oral administration of different probiotic strains (LcS, Streptococcus thermophilus, Lactobacillus fermentum, yeast) to mice.
  • Assessment of immune responses, including NK cell activity, cytokine production, antibody levels, and cellular immunity against specific antigens like Ovalbumin (OVA).
  • Evaluation of tumor cell growth inhibition by LcS.

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Main Results:

  • LcS enhanced innate immunity and Th1 cytokine production, suppressing IgE antibodies against OVA.
  • Other probiotics elicited varied immune responses; some enhanced responses to OVA vaccination, while others suppressed them.
  • Cofeed antigen with probiotics suppressed both antibody and cellular immune responses.

Conclusions:

  • Probiotics can switch mucosal immune responses, offering a strategy for allergic disorder treatment.
  • Probiotic co-feeding with antigens may attenuate autoimmune diseases by suppressing immune responses.