Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The third function of the thymus.

B Seddon1, D Mason

  • 1Division of Molecular Immunology, National Institute for Medical Research, The Ridgeway, Mill Hill, London, UK NW7 1AA.

Immunology Today
|February 1, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Search for charged Higgs bosons produced in vector boson fusion processes and decaying into vector boson pairs in proton-proton collisions at <math> </math>.

The European physical journal. C, Particles and fields·2021
Same author

Search for a heavy vector resonance decaying to a <math></math>  boson and a Higgs boson in proton-proton collisions at <math> </math>.

The European physical journal. C, Particles and fields·2021
Same author

Measurement of the Higgs boson production rate in association with top quarks in final states with electrons, muons, and hadronically decaying tau leptons at <math> </math>.

The European physical journal. C, Particles and fields·2021
Same author

Measurements of production cross sections of the Higgs boson in the four-lepton final state in proton-proton collisions at <math> </math>.

The European physical journal. C, Particles and fields·2021
Same author

MUSiC: a model-unspecific search for new physics in proton-proton collisions at <math> </math>.

The European physical journal. C, Particles and fields·2021
Same author

Measurements of angular distance and momentum ratio distributions in three-jet and <math></math> + two-jet final states in <math></math> collisions.

The European physical journal. C, Particles and fields·2021
Same journal

Foreword.

Immunology today·2020
Same journal

The origin and significance of anti-DNA antibodies.

Immunology today·2014
Same journal

Mutations of class II MHC molecules.

Immunology today·2014
Same journal

Antigen processing at the molecular level.

Immunology today·2014
Same journal

Phenotypically and functionally distinct T-cell subsets in anti-tumor responses.

Immunology today·2014
Same journal

Are MHC class II-restricted cytotoxic T lymphocytes important?

Immunology today·2014
See all related articles

Mammalian T cells normally ignore self-antigens, preventing autoimmune disease. This study reveals a T-cell mechanism that maintains self-tolerance and explains how its failure leads to autoimmunity.

Area of Science:

  • Immunology
  • Autoimmunity
  • T-cell biology

Background:

  • Mammalian T cells can recognize self-antigens, posing a risk for autoimmune disease.
  • Established mechanisms like clonal deletion, anergy, and ignorance do not fully explain self-tolerance.
  • The T-cell repertoire contains cells with potential autoimmune reactivity.

Purpose of the Study:

  • To describe a T-cell-mediated mechanism responsible for preventing autoimmune reactions to self-antigens.
  • To elucidate how the failure of this mechanism contributes to the development of autoimmunity.

Main Methods:

  • Review of existing immunological studies on T-cell self-recognition.
  • Analysis of T-cell repertoire composition in healthy individuals.
  • Description of a T-cell-mediated regulatory pathway.

Related Experiment Videos

Main Results:

  • Identified a T-cell-mediated mechanism crucial for maintaining nonresponsiveness to self-antigens.
  • Demonstrated that this mechanism acts in addition to clonal deletion, anergy, and ignorance.
  • Highlighted the link between the failure of this mechanism and autoimmune disease pathogenesis.

Conclusions:

  • A novel T-cell-mediated pathway is essential for preventing autoimmunity.
  • Dysregulation of this pathway represents a critical factor in the development of autoimmune conditions.
  • Understanding this mechanism offers potential therapeutic targets for autoimmune diseases.