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Signal transduction from the angiotensin II AT2 receptor
1CNRS UPR415, Institut Cochin de Génétique Moléculaire, 22 rue Méchain, 75014 Paris, France.
Trends in Endocrinology and Metabolism: TEM
|February 1, 2000
Abstract:
Recent studies of genetically engineered animals have established a role for the angiotensin II (AT2) receptor in cardiovascular, renal and central functions, as well as in developmental processes. This review summarizes new insights into major AT2 signaling pathways--activation of protein phosphatases, the nitric oxide-cGMP system and phospholipase A2--which have been related to specific cellular responses or functions of this receptor.