Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Is CREB a key to neuronal survival?

M R Walton1, I Dragunow

  • 1Dept of Pharmacology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.

Trends in Neurosciences
|February 1, 2000
PubMed
Summary

The transcription factor cAMP-response-element-binding protein (CREB) may be responsible for programmed nerve cell survival. Further research is needed to confirm CREB's role in the brain and identify its downstream survival genes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Use of selective inhibitors and chromogenic substrates to differentiate bacteria based on toluene oxygenase activity.

Journal of microbiological methods·2001
Same author

PU.1 expression in microglia.

Journal of neuroimmunology·2000
Same author

Bax expression in mammalian neurons undergoing apoptosis, and in Alzheimer's disease hippocampus.

Brain research·1997
Same author

Chemical and operative lumbar sympathectomy.

The British journal of clinical practice·1981
Same author

Cancer chemotherapy.

The British journal of clinical practice·1972

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Cell Biology

Background:

  • Nerve-cell survival in the brain is regulated by various molecules.
  • Many neuroprotective molecules may function by activating the transcription factor cAMP-response-element-binding protein (CREB).

Purpose of the Study:

  • To investigate the role of CREB in programmed nerve-cell survival.
  • To identify downstream survival genes regulated by CREB in neurons.

Main Methods:

  • The study reviews existing research on CREB activation and its effects on cell survival.
  • Focuses on in vitro findings and suggests in vivo studies.

Main Results:

  • CREB activation, through phosphorylation at Ser133, occurs in resistant hippocampal cells and is triggered by stimuli.
  • The Akt signaling pathway activates CREB, promoting survival in vitro.
  • CREB synthesis and phosphorylation enhance survival of various cells, including neurons.

Conclusions:

  • CREB is a potential key player in programmed nerve-cell survival.
  • Further in vivo studies are required to validate these findings in the brain.
  • Identification of CREB-activated downstream survival genes in neurons is crucial.

Related Experiment Videos