Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gap junctions, synchrony and seizures.

J L Perez Velazquez1, P L Carlen

  • 1Playfair Neuroscience Unit, Bloorview Epilepsy Programme, Depts of Medicine (Neurology) and Physiology, University of Toronto, Toronto Western Hospital, Toronto, Ontario, Canada M5T 2S8.

Trends in Neurosciences
|February 1, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lysergic acid diethylamide modulates hippocampal and cortical local field potential oscillatory rhythms in male mice.

Brain research·2026
Same author

Measures of entropy and complexity in altered states of consciousness.

Cognitive neurodynamics·2018
Same author

Consciousness as a global property of brain dynamic activity.

Physical review. E·2018
Same author

Statistical mechanics of consciousness: Maximization of information content of network is associated with conscious awareness.

Physical review. E·2016
Same author

High sensitivity of spontaneous spike frequency to sodium leak current in a Lymnaea pacemaker neuron.

The European journal of neuroscience·2016
Same author

Hypoglycemia-induced alterations in hippocampal intrinsic rhythms: Decreased inhibition, increased excitation, seizures and spreading depression.

Neurobiology of disease·2015
Same journal

Building neuroscience capacity in low- and middle-income countries: Lessons from Ghana.

Trends in neurosciences·2026
Same journal

Emulating the periodic table: A unified list of CNS terms and abbreviations for humans and experimental animals.

Trends in neurosciences·2026
Same journal

From chromatin dynamics to brain disease: Polycomb-Trithorax mechanisms in neurodevelopment.

Trends in neurosciences·2026
Same journal

Striatum regulates the cortex via the basal forebrain cholinergic system: A role for substance P.

Trends in neurosciences·2026
Same journal

A large brain adds new types of neurons: Molecular and functional signatures of spindle neurons in the human neocortex.

Trends in neurosciences·2026
Same journal

Exercise as a regulator of glymphatic function.

Trends in neurosciences·2026
See all related articles

Direct intercellular connections between neurons, known as gap junctions, are crucial for coordinating brain activity. This research highlights their role in neuronal synchronization and the development of seizures.

Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Cellular Neuroscience

Background:

  • The role of direct intercellular cytoplasmic connections between neurons in coordinating activity has been historically debated.
  • Recent theoretical and experimental findings suggest renewed importance for these connections, particularly in neuronal synchronization and epileptogenesis.

Purpose of the Study:

  • To investigate the significance of gap-junctional communication in neuronal synchronization and its implications for brain rhythms.
  • To explore the interplay between electrotonic coupling and cellular/synaptic properties in neuronal network function.

Main Methods:

  • Utilized computer simulations to model neuronal synchronization based on varying levels of gap-junctional communication.
  • Conducted experimental manipulations targeting gap-junctional communication to observe effects on neuronal firing and seizure activity.

Related Experiment Videos

Main Results:

  • Computer simulations demonstrated that gap-junctional communication influences neuronal synchronization and firing patterns.
  • Experimental data confirmed that modulating gap-junctional communication affects the generation and maintenance of synchronized neuronal firing and seizures.

Conclusions:

  • Direct electrotonic coupling through gap junctions plays a significant role in coordinating neuronal activity.
  • Gap junctions contribute to both normal physiological brain rhythms and abnormal activity, such as seizures, alongside chemical transmission.