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Exercise as a regulator of glymphatic function
James R Broatch1, Nicholas J Saner1, Melinda L Jackson2
1Exercise Prescription Laboratory, Institute for Health and Sport (IHES), Victoria University, Footscray, Victoria, Australia.
Trends in Neurosciences
|June 30, 2026
Summary
Exercise may enhance the brain
Area of Science:
- Neuroscience
- Physiology
Background:
- The glymphatic system clears brain waste, including proteins linked to neurodegenerative diseases.
- Exercise may offer neuroprotection by influencing this system.
Purpose of the Study:
- To review evidence on glymphatic system function, regulation, and its link to exercise.
- To propose exercise as a modulator of glymphatic integrity.
Main Methods:
- Literature review of animal and human studies.
- Synthesis of data on glymphatic system organization and regulation.
- Analysis of exercise's physiological adaptations and their impact on the glymphatic system.
Main Results:
- The glymphatic system's role in waste clearance is increasingly recognized.
- Exercise shows potential to modulate glymphatic function.
- Aging and neurodegeneration can impair glymphatic function.
Conclusions:
- Exercise may enhance glymphatic function, contributing to brain resilience.
- Physiological adaptations to exercise provide a framework for understanding exercise's neuroprotective effects.
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