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Updated: Aug 14, 2026

Social Isolation Model: A Noninvasive Rodent Model of Stress and Anxiety
Published on: November 11, 2022
An epigenetic view of anxiety disorders, one cell type at a time
Klara Mareckova1, Yuliya S Nikolova2
1Brain and Mind Research Programme, Central European Institute of Technology, Masaryk University (CEITEC MU), Brno, Czech Republic; First Department of Neurology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Abstract:
A recent publication by Ingram et al. revealed the importance of cellular precision in psychiatric epigenetics. Using cellular deconvolution, the authors showed that anxiety is associated with cell type-specific DNA methylation signatures reflecting stress, inflammation, and accelerated aging. These findings have critical implications for neuroscience studies aiming to bridge the gap between the peripheral epigenome and brain function.
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