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The Microglia-Astrocyte-Neuron Lactate Shuttle model
Eduardo R Zimmer1, Anne-Karine Bouzier-Sore2, Luc Pellerin3
1Neuroscience Unit, Hospital Moinhos de Vento, Porto Alegre, Brazil; Department of Pharmacology, Institute of Health Basic Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; Graduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; Graduate Program in Biological Sciences: Pharmacology and Therapeutics, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Abstract:
In a recent study, Adler and colleagues demonstrated that microglia regulate blood glucose delivery to fuel the astrocyte-neuron lactate shuttle. As neuronal protein translation supported by this mechanism is essential for motor learning, these findings reveal how coordinated interactions among microglia, astrocytes, and neurons orchestrate neuroenergetics to support cognition.
