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Established rheumatoid arthritis.

P G Conaghan1, M J Green, P Emery

  • 1Rheumatology and Rehabilitation Research Unit, University of Leeds, England.

Bailliere'S Best Practice & Research. Clinical Rheumatology
|February 1, 2000
PubMed
Summary
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Diagnosing rheumatoid arthritis (RA) early is crucial for better outcomes. Identifying patients with poor prognosis and using early, targeted therapies, including qualitative markers like rheumatoid factor (RF), improves long-term results.

Area of Science:

  • Rheumatology
  • Immunology
  • Clinical Medicine

Background:

  • Diagnosing rheumatoid arthritis (RA) can be challenging, particularly in early stages.
  • Current American College of Rheumatology (ACR) criteria are more effective for long-standing disease.
  • Recent imaging reveals joint damage even in early RA, blurring the distinction between early and established disease.

Purpose of the Study:

  • To emphasize the importance of early RA diagnosis.
  • To highlight the need for identifying patients with poor prognosis for targeted therapy.
  • To advocate for intensive disease control regardless of disease duration.

Main Methods:

  • Review of current diagnostic criteria for RA.
  • Analysis of prognostic markers in early and established RA.

Related Experiment Videos

  • Consideration of modern therapeutic strategies and their impact.
  • Main Results:

    • Early diagnosis of RA remains difficult due to lack of specific criteria.
    • Qualitative markers like rheumatoid factor (RF) and shared epitope are crucial in early, pre-erosive RA.
    • Quantitative markers like C-reactive protein (CRP) provide prognostic information in established disease.

    Conclusions:

    • Early and accurate diagnosis of RA is paramount for effective management.
    • Identifying high-risk patients early allows for timely, targeted interventions.
    • Intensified disease control strategies can lead to better long-term outcomes in RA patients.