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Congenital cutaneous candidiasis: clinical presentation, pathogenesis, and management guidelines
Pediatrics
|February 2, 2000
Summary
Congenital cutaneous candidiasis (CCC) in neonates is linked to intrauterine foreign bodies and preterm birth. Infants under 1000g face higher risks of severe dermatitis, systemic infection, and death.
Area of Science:
- Neonatal Dermatology
- Infectious Diseases
- Perinatology
Background:
- Congenital cutaneous candidiasis (CCC) is a rare neonatal fungal infection.
- Intrauterine foreign bodies are identified as a potential predisposing factor for CCC and preterm birth.
Observation:
- CCC presentation varies by birth weight.
- Neonates >1000g typically show generalized erythematous macules, papules, or pustules.
- Neonates <1000g often present with desquamating/erosive dermatitis.
Findings:
- Extremely low birth weight neonates (<1000g) have a higher incidence of severe dermatitis (67%).
- These infants also face increased risks of systemic Candida infection (67%) and mortality (40%).
- Neonates >1000g have lower rates of systemic infection (10%) and death (8%).
Implications:
- Systemic antifungal therapy is recommended for neonates with severe CCC, positive cultures, or signs of sepsis.
- Consider systemic treatment for infants with respiratory distress or laboratory signs of sepsis.
- Early recognition and management are crucial for improving outcomes in neonates with CCC.