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Updated: Aug 15, 2026
08:04
Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation
Published on: July 9, 2014
What's Old Is New Again: Varicella
Caitlin Naureckas Li1, Kathryn M Edwards2, Sheldon L Kaplan3
1Division of Infectious Diseases, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.
Pediatrics
|August 13, 2026
Summary
Varicella vaccination significantly reduces chickenpox cases. This review helps clinicians address vaccine hesitancy and manage varicella zoster virus infections effectively.
Area of Science:
- Infectious Diseases
- Vaccinology
- Public Health
Background:
- Varicella vaccine availability has drastically reduced chickenpox incidence.
- Increasing vaccine hesitancy presents challenges for healthcare providers.
- Clinicians frequently encounter patient questions regarding varicella zoster virus (VZV).
Purpose of the Study:
- To provide clinicians with updated information on varicella vaccination.
- To equip healthcare professionals to address vaccine hesitancy.
- To guide the recognition, treatment, and spread mitigation of VZV infections.
Main Methods:
- State-of-the-art review of current literature on varicella.
- Synthesis of evidence regarding vaccine efficacy and safety.
- Guidance on clinical management and public health strategies.
Main Results:
- Varicella vaccination is a highly effective public health intervention.
- Addressing parental concerns about VZV vaccines requires clear, evidence-based communication.
- Prompt diagnosis and management are crucial for limiting VZV transmission.
Conclusions:
- Continued emphasis on varicella vaccination is essential for disease control.
- Healthcare providers play a vital role in combating vaccine hesitancy.
- Comprehensive understanding of VZV is necessary for effective clinical practice and prevention.
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