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FGFs, heparan sulfate and FGFRs: complex interactions essential for development.

¹Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, MO 63110, USA. dornitz@pcg.wustl.edu

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology

|February 2, 2000

Summary

Heparan sulfate is essential for fibroblast growth factor (FGF) signaling in vivo. This finding demonstrates FGF

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Area of Science:

Developmental biology
Cell signaling
Biochemistry

Background:

Fibroblast growth factors (FGFs) are key signaling molecules.
FGFs bind to heparin and cell surface heparan sulfate proteoglycans.
Heparan's role in FGF receptor complex formation is supported by biochemical evidence.

Purpose of the Study:

To demonstrate the in vivo requirement of heparan for FGF biological activity.
To investigate FGF function in a developmental system.

Main Methods:

Utilized Drosophila melanogaster as a model system.
Investigated the role of heparan sulfate in FGF signaling pathways.

Main Results:

Demonstrated that heparan sulfate is essential for FGF function during Drosophila development.

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Provided the first in vivo evidence for heparan's requirement in FGF signaling.

Conclusions:

Heparan sulfate plays a critical role in FGF-mediated developmental processes.
Tissue-specific heparan structures may modulate FGF activity.