Fatal nefopam overdose

Area of Science:

• Pharmacology
• Toxicology
• Clinical Medicine

Background:

• Nefopam is a non-opioid analgesic acting centrally.
• It affects neurotransmitter reuptake (serotonin, norepinephrine, dopamine).
• Known adverse effects include CNS, cardiovascular, and renal issues.

Observation:

• A young woman experienced nefopam overdose.
• She presented with symptoms affecting multiple organ systems.
• These symptoms aligned with known nefopam toxicity.

Findings:

• The patient died following the nefopam overdose.
• Her clinical presentation included confusion, tachycardia, and renal failure.
• This represents the second reported death due to nefopam overdose in literature.

Implications:

• Nefopam overdose carries a significant risk of mortality.
• Clinicians should be aware of severe adverse events, including fatalities.
• This case underscores the importance of cautious prescribing and overdose management.