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Effects of glucagon, insulin, amylin and CGRP on feeding
1E. W. Bourne Behavioral Research Laboratory, New York Presybterian Hospital and Weill Medical College of Cornell University, White Plains, NY, 10605, USA.
Abstract:
The roles of the pancreatic peptides glucagon, insulin, and amylin in the inhibitory control of feeding are reviewed. Calcitonin gene-related peptide (CGRP) is also included because it is structurally and functionally related to amylin and because known amylin and CRRP receptors are activated by both peptides. Glucagon-like peptide 1, in contrast, is structurally distinct from pancreatic glucagon and does not cross-react with glucagon receptors, so it is not considered. Several detailed reviews of the feeding effects of these peptides have appeared recently; where appropriate, these are cited rather than the primary literature.