Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The ageing lens.

A J Bron1, G F Vrensen, J Koretz

  • 1Nuffield Laboratory of Ophthalmology, University of Oxford, UK.

Ophthalmologica. Journal International D'Ophtalmologie. International Journal of Ophthalmology. Zeitschrift Fur Augenheilkunde
|February 5, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Basal Tear Osmolarity as a metric to estimate body hydration and dry eye severity.

Progress in retinal and eye research·2018
Same author

Clinical staining of the ocular surface: mechanisms and interpretations.

Progress in retinal and eye research·2014
Same author

The ageing lens and cataract: a model of normal and pathological ageing.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2011
Same author

NADPH-diaphorase expression in the meibomian glands of rat palpebra in postnatal development.

European journal of histochemistry : EJH·2011
Same author

Role of keratan sulphate (sulphated poly -N-acetyllactosamine repeats) in keratoconic cornea, histochemical, and ultrastructural analysis.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie·2010
Same author

A mass and solute balance model for tear volume and osmolarity in the normal and the dry eye.

Progress in retinal and eye research·2009
Same journal

The risk of retinal vascular events in patients using semaglutide: a scoping review.

Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde·2026
Same journal

Interpreting relative afferent pupillary defect in Leber hereditary optic neuropathy using interocular visual acuity difference.

Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde·2026
Same journal

1 MONTH VS. 3 MONTHS HEAVY SILICONE OIL TAMPONADE IN COMPLEX RHEGMATOGENOUS RETINAL REDETACHMENT.

Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde·2026
Same journal

Visual loss after silicone oil removal - Analysis of a German cohort.

Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde·2026
Same journal

Weekend effect on vitrectomy: Insights from a Nationwide Population-Based Study in Korea.

Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde·2026
Same journal

The Royal College of Ophthalmologists National Ophthalmology Database Age-related Macular Degeneration (AMD) Audit, Report 2: Baseline characteristics, the care pathway and 12-month visual acuity and safety outcomes for 54,882 eyes starting treatment for neovascular AMD.

Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde·2026
See all related articles

The human lens grows throughout life, but aging causes crystallin insolubilization and molecular damage, impairing vision and leading to presbyopia and potential cataract formation.

Area of Science:

  • Ophthalmology
  • Cell Biology
  • Biochemistry

Background:

  • The human lens continuously grows via epithelial cell division and fiber cell differentiation.
  • Despite growth in a closed system, the lens maintains transparency and image-forming ability.
  • Lens cells cannot be shed, necessitating continuous remodeling and repair mechanisms.

Purpose of the Study:

  • To explore the mechanisms of human lens growth and aging.
  • To understand how the lens maintains optical clarity despite cumulative molecular damage.
  • To identify factors contributing to age-related vision changes like presbyopia and cataract.

Main Methods:

  • Review of lens growth processes, including cell division and fiber differentiation.
  • Analysis of molecular changes in the lens with age, including protein modification and aggregation.

Related Experiment Videos

  • Investigation of factors affecting light transmission and image formation in the aging lens.

    • Main Results:

    • Lens aging involves crystallin insolubilization and aggregate formation, reducing nuclear deformability and causing presbyopia.
    • Accumulation of glutathione-3-hydroxy kynurenine glycoside contributes to lens yellowing and increased fluorescence.
    • Age-related changes include increased light scatter, spectral absorption, and microscopic focal changes, precursors to cortical cataract.

    Conclusions:

    • Lens aging is a complex process involving structural and molecular alterations that compromise visual function.
    • Protective scavenger and chaperone molecules mitigate damage, but cumulative effects lead to age-related vision impairment.
    • Understanding these aging processes is crucial for addressing presbyopia and cataract development.