Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hypothyroidism in primary hyperoxaluria type 1.

Y Frishberg1, S Feinstein, C Rinat

  • 1Division of Pediatric Nephrology, Shaare Zedek Medical Center and Hebrew University, Haddasah Medical School, Jerusalem, Israel.

The Journal of Pediatrics
|February 5, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Recurrent nephrotic syndrome in homozygous truncating NPHS2 mutation is not due to anti-podocin antibodies.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2006
Same author

Prevalence of complications in children with chronic kidney disease according to KDOQI.

Kidney international·2006
Same author

Calculus in a toddler with end-stage renal disease due to prune-belly syndrome.

Oral diseases·2006
Same author

Clinical and biochemical manifestations and molecular characterization of the mutation HPRT Jerusalem.

Nucleosides, nucleotides & nucleic acids·2004
Same author

The use of Luria's method for the neurobehavioral assessment of encephalopathy in an adolescent: application in a rehabilitation setting.

Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists·2003
Same author

The renal hemodynamic effects of Aspirin in newborn and young adult rabbits.

Pediatric nephrology (Berlin, Germany)·2001
Same journal

Respiratory Syncytial Virus Immunization Disparities in Mothers and Infants at the Birth Hospitalization: A Cross-Sectional Study.

The Journal of pediatrics·2026
Same journal

Blood-Based Biomarkers Predict Cerebral Palsy and Cognitive Delay in Hypoxic-Ischemic Encephalopathy: A Secondary Analysis of the HEAL Randomized Controlled Trial.

The Journal of pediatrics·2026
Same journal

Does Mild Head Injury in Childhood Affect Later School Performance? A Sibling Comparison Cohort Study.

The Journal of pediatrics·2026
Same journal

Risk Factors for Mortality and Age at Discharge in Preterm Infants with Congenital Heart Disease.

The Journal of pediatrics·2026
Same journal

To Cool or Not to Cool in Low- and Middle-Income Countries:? A Call for Resources, Training and Shared Knowledge.

The Journal of pediatrics·2026
Same journal

Responsible Research Practices in Pediatrics: How Reporting Guidelines Can Be Used to Improve Trial Design and Conduct.

The Journal of pediatrics·2026
See all related articles

Severe hypothyroidism in patients with primary hyperoxaluria type 1 (PH1) and oxalosis may stem from calcium oxalate deposits. Thyroid hormone replacement therapy proved effective, highlighting the need for thyroid monitoring in PH1 patients.

Area of Science:

  • Nephrology
  • Endocrinology
  • Metabolic Disorders

Background:

  • Primary hyperoxaluria type 1 (PH1) is a rare genetic disorder leading to excessive oxalate production and deposition.
  • End-stage renal disease (ESRD) is a common complication of PH1 due to kidney damage from calcium oxalate crystals.
  • Oxalosis, the systemic deposition of calcium oxalate in various tissues, can cause multi-organ dysfunction.

Observation:

  • This study reports on four patients with PH1 and ESRD who presented with severe, symptomatic hypothyroidism.
  • Patients ranged in age from 3 months to 23 years.
  • All patients exhibited diffuse calcium oxalate deposition in kidneys, skeleton, eyes, and heart.

Findings:

  • Hypothyroidism in these patients was responsive to thyroid hormone replacement therapy.

Related Experiment Videos

  • The hypothyroidism is hypothesized to result from thyroid tissue damage caused by extensive calcium oxalate accumulation.
  • This suggests a direct link between oxalosis and endocrine dysfunction in PH1.

    • Implications:

    • Thyroid function should be routinely monitored in patients diagnosed with PH1 and oxalosis.
    • Early detection and management of hypothyroidism may improve outcomes for PH1 patients.
    • Understanding the impact of oxalosis on endocrine organs is crucial for comprehensive patient care.