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Related Experiment Videos

Chronic bradykinin receptor blockade modulates neonatal renal function.

P Tóth-Heyn1, D Mosig, J P Guignard

  • 1Service de Pédiatrie, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.

Biology of the Neonate
|February 5, 2000
PubMed
Summary

Bradykinin receptor blockade in newborn rabbits did not affect kidney growth but altered renal blood flow. An intact kallikrein-kinin system is essential for normal kidney functional development.

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Area of Science:

  • Nephrology
  • Developmental Biology
  • Pharmacology

Background:

  • Bradykinin plays a role in neonatal glomerular function and renal development.
  • Its specific involvement in renal functional maturation requires further investigation.

Purpose of the Study:

  • To examine the role of bradykinin in the maturation of renal function in newborn rabbits.

Main Methods:

  • Newborn rabbits were treated with a bradykinin beta2-receptor antagonist (Hoe 140) or saline for 4 days.
  • Clearance studies were conducted in 8-9 day old rabbits to assess renal function.

Main Results:

  • Bradykinin receptor blockade did not impact kidney weight or blood pressure.
  • Treated rabbits showed increased renal blood flow, decreased renal vascular resistance, and lower filtration fraction.

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  • Glomerular filtration rate remained unchanged.

    • Conclusions:

    • Bradykinin receptor blockade did not hinder kidney growth or blood pressure.
    • The observed changes in renal hemodynamics suggest a complex role for bradykinin.
    • An intact kallikrein-kinin system is crucial for normal kidney functional development.