Jove
Visualize
Contact Us

Related Experiment Videos

Problems associated with sterilization using ethylene oxide. Residues in treated materials.

I Buben1, V Melichercíková, N Novotná

  • 1State Institute for Drug Control, Prague, Czech Republic.

Central European Journal of Public Health
|February 5, 2000
PubMed
Summary

This study addresses ethylene oxide (EO) residues in medical devices, emphasizing careful sterilization and aeration processes to minimize patient health risks. It classifies polymers based on EO sterilization suitability and highlights issues with older sterilizers.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Susceptibility of clinical isolates of Bordetella pertussis to chemicals.

Epidemiologie, mikrobiologie, imunologie : casopis Spolecnosti pro epidemiologii a mikrobiologii Ceske lekarske spolecnosti J.E. Purkyne·2019
Same author

Residual effect of antiseptic substances on human skin.

The Journal of hospital infection·2010
Same author

[The use of gas chromatography in pharmacognosy: cooperation of the State Institute for Drug Control and the Department of Pharmacognosy, Faculty of Pharmacy in Hradec Králové, Charles University in Prague. II. Standardization of essentials oils].

Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti·2006
Same author

[The use of gas chromatography in pharmacognosy: cooperation of the State Institute for Drug Control and the Department of Pharmacognosy, Faculty of Pharmacy in Hradec Králové, Charles University in Prague. I. Determination of pesticides residues in medicinal plants].

Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti·2006
Same author

[Microbicidal effect of Lautercide, a new disinfectant].

Ceskoslovenska epidemiologie, mikrobiologie, imunologie·1992
Same author

New disinfectants.

Acta Universitatis Palackianae Olomucensis Facultatis Medicae·1991
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Area of Science:

  • Materials Science
  • Medical Device Sterilization
  • Polymer Chemistry

Background:

  • Ethylene oxide (EO) sterilization is common for medical devices but can leave harmful residues.
  • Assessing and reducing EO residues is crucial for patient safety.
  • Understanding polymer behavior during sterilization is essential for device integrity.

Purpose of the Study:

  • To investigate the impact of material type and sterilization/aeration conditions on EO residue levels.
  • To classify polymers based on their suitability for EO sterilization or re-sterilization.
  • To evaluate the effectiveness of different sterilization and aeration processes.

Main Methods:

  • Conducted model sterilizations using actual medical device components with known compositions.

Related Experiment Videos

  • Assessed EO concentrations under varying sterilization and aeration conditions.
  • Compared results from model sterilizations with those from devices obtained from medical institutions.

    • Main Results:

    • Identified specific polymers as suitable or unsuitable for ethylene oxide sterilization/re-sterilization.
    • Demonstrated that model sterilizations with known compositions are more reliable than analyzing aged devices.
    • Observed poor reproducibility in older sterilizers, particularly those with inadequate aeration.

    Conclusions:

    • Polymer selection is critical for safe and effective ethylene oxide sterilization.
    • Validated sterilization and aeration protocols are necessary to control EO residues.
    • Modern sterilizers with effective aeration are essential for consistent and reliable results.