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Urinary fluoride excretion in small children following short-term fluoride supply with tablets or domestic salt

I Hellström, Y Ericsson

    Scandinavian Journal of Dental Research
    |July 1, 1976
    PubMed

    Insights

    Fluoride (F) salt supplementation in children significantly increased urinary F excretion, comparable to tablet doses. This suggests fluoridated salt is a viable option for caries prevention in larger populations.

    Area of Science:

    • Public Health
    • Dental Health
    • Environmental Health

    Background:

    • Urinary fluoride (F) excretion is a key indicator of fluoride intake and metabolism.
    • Previous studies have examined fluoride excretion in children, with limited comparisons to adults.
    • Fluoridated salt (F-salt) is a potential public health intervention for caries prevention.

    Purpose of the Study:

    • To investigate urinary fluoride excretion in children following ingestion of fluoride tablets and fluoridated salt.
    • To compare fluoride excretion patterns between children and adults.
    • To assess the suitability of domestic fluoridated salt for large-scale clinical testing.

    Main Methods:

    • Measurement of 24-hour urinary fluoride (F) levels in children of various ages and settings (institution vs. families).
    • Administration of fluoride tablets (NaF) and meals prepared with fluoridated salt (500 mg F/kg NaCl).
    • Comparison of urinary F concentrations and percentage of F dose excreted over time in children and adults.

    Main Results:

    • 24-h urinary F levels increased significantly in children consuming F-salt, with higher levels observed in institutionalized children.
    • Children consuming two F-salted meals daily showed elevated urinary F, but not with one meal.
    • Urinary F concentrations in children after NaF tablets matched those of children on long-term tablet use; dose excretion percentages were similar in children and adults.

    Conclusions:

    • Ingestion of F-salt leads to increased urinary F excretion in children, indicating systemic absorption.
    • The fluoride absorption and excretion profile from F-salt is comparable to NaF tablets in children and adults.
    • Domestic salt containing approximately 500 parts/10^6 F is suitable for larger-scale clinical trials in Sweden.

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