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Related Experiment Videos

Oxalate excretion during carbohydrate infusions.

D W Thomas, B Hannett, A Chalmers

    Internationale Zeitschrift Fur Vitamin- Und Ernahrungsforschung. Beiheft
    |January 1, 1976
    PubMed
    Summary

    Vitamin B-6 deficiency significantly increases oxalate production when consuming xylitol. Correcting this deficiency normalizes oxalate metabolism, indicating xylitol

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    Area of Science:

    • Biochemistry
    • Nutritional Science
    • Metabolic Pathways

    Background:

    • Oxalate metabolism is crucial for preventing kidney stone formation.
    • Vitamin B-6 plays a role in various metabolic processes, including amino acid metabolism.
    • Xylitol is a sugar alcohol used as a sweetener, and its metabolic fate is not fully understood in all contexts.

    Purpose of the Study:

    • To investigate the impact of xylitol infusion on oxalate metabolism in rats with varying vitamin B-1 and B-6 levels.
    • To determine the specific role of vitamin B-6 deficiency in xylitol-induced oxalate production.

    Main Methods:

    • Normal and vitamin B-6 deficient rats were infused intravenously with solutions containing glucose, fructose, sorbitol, or xylitol.
    • Urinary excretion of oxalate, glyoxylate, and glycine was measured.
    • Rats were infused with U 14C-xylitol to trace metabolic pathways.
    • Vitamin B-6 deficiency was corrected in some rats to observe the effects on oxalate excretion.

    Main Results:

    • Vitamin B-6 deficient rats infused with xylitol showed significantly increased urinary oxalate, glyoxylate, and glycine.
    • 14C-oxalate was excreted only in vitamin B-6 deficient rats infused with U 14C-xylitol.
    • Correcting vitamin B-6 deficiency normalized urinary oxalate excretion and the percentage of U 14C-xylitol excreted as 14C-oxalate.

    Conclusions:

    • Xylitol metabolism appears to enhance pathways leading to oxalate formation specifically in the context of vitamin B-6 deficiency.
    • Vitamin B-6 is essential for regulating oxalate production during xylitol metabolism.
    • These findings highlight a potential metabolic interaction between xylitol intake and vitamin B-6 status relevant to oxalate homeostasis.

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