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Related Experiment Videos

Bioabsorbable thread for tight tying of bones.

K Hattori1, N Tomita, S Tamai

  • 1Department of Orthopaedic Surgery, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-0813, Japan.

Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association
|February 9, 2000
PubMed
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A new bioabsorbable thread made from poly(L-lactic acid) and poly(epsilon-caprolactone) offers strong bone fracture fixation. This innovative blend demonstrates superior fatigue strength and minimal loosening compared to traditional metal wires.

Area of Science:

  • Biomaterials Science
  • Orthopedic Surgery
  • Polymer Science

Background:

  • Fracture fixation often relies on non-bioabsorbable materials like metal wires.
  • These materials can lead to complications such as stress shielding and the need for secondary removal surgeries.
  • Development of bioabsorbable alternatives is crucial for improving patient outcomes.

Purpose of the Study:

  • To develop and evaluate a novel bioabsorbable thread for secure bone fracture fixation.
  • To assess the mechanical properties, specifically tying strength and fatigue resistance, of the bioabsorbable thread.
  • To investigate the biocompatibility of the developed thread in an in-vivo model.

Main Methods:

  • A bioabsorbable thread was fabricated using a blend of poly(L-lactic acid) (PLLA) and poly(epsilon-caprolactone) (PCL) fibers.

Related Experiment Videos

  • Fusion welding was employed to connect the PCL fibers for secure tying.
  • Mechanical testing included measurement of tying strength and fatigue strength using a custom testing machine simulating bone fixation.
  • In-vivo biocompatibility was assessed through testing in rats to evaluate inflammatory responses.

    • Main Results:

    • The PLLA-PCL blend thread exhibited a tying strength of 39.7 N, comparable to stainless steel wire.
    • In fatigue testing, metal wires failed within 25,000 loading cycles, while the blend threads withstood over 50,000 cycles without failure.
    • Looseness of the blend thread fixation remained within 1mm after 50,000 loading cycles.
    • In-vivo studies in rats showed no severe inflammatory reactions associated with the blend thread.

    Conclusions:

    • The developed PLLA-PCL bioabsorbable thread provides robust and durable fixation for fractured bones.
    • Its mechanical performance, particularly fatigue resistance, surpasses that of traditional metal wires.
    • The bioabsorbable thread demonstrates excellent biocompatibility, presenting a promising alternative for orthopedic applications.