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Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
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Patients with hypertrophic cardiomyopathy (HCM) and left ventricular outflow tract (LVOT) obstruction who remain symptomatic despite optimal medical therapy may undergo a septal myectomy (Morrow procedure). This procedure involves excising a portion of the hypertrophied septum below the aortic valve using a heart-lung machine to improve blood flow through the LVOT. Effective preoperative and postoperative nursing management ensures successful patient outcomes, minimizes complications, and...
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Related Experiment Video

Updated: Jul 17, 2026

Use of a Hanging-weight System for Isolated Renal Artery Occlusion
07:54

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Published on: July 19, 2011

Heparin-coated circuits prevent renal dysfunction after open heart surgery.

S Suehiro1, T Shibata, Y Sasaki

  • 1Department of Cardiovascular Surgery, Osaka City University Medical School, Japan. shigefumis@msic.med.osaka-cu.ac.Jp

Osaka City Medical Journal
|March 24, 2000
PubMed
Summary

Heparin-coated circuits improve operative results for patients with chronic kidney disease undergoing cardiac surgery. These circuits help maintain renal function and may reduce the need for dialysis.

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Area of Science:

  • Cardiovascular Surgery
  • Nephrology
  • Biomaterials Science

Background:

  • Chronic renal insufficiency poses risks during cardiac surgery.
  • Cardiopulmonary bypass can exacerbate kidney dysfunction.

Purpose of the Study:

  • To evaluate the efficacy of heparin-coated (HC) circuits in patients with chronic renal insufficiency undergoing cardiac surgery.
  • To assess the impact of HC circuits on operative outcomes and renal function preservation.

Main Methods:

  • Elective cardiac surgery was performed on 24 patients with serum creatinine ≥ 1.5 mg/dl.
  • Patients were divided into two groups: 12 receiving uncoated circuits and 12 receiving HC circuits.
  • Surgical results and renal function markers were compared between groups.

Main Results:

  • The HC group had higher preoperative creatinine levels (2.3 vs 1.8 mg/dl).
  • Lower heparin and protamine doses and shorter activated clotting times were observed in the HC group.
  • The HC group showed a smaller postoperative increase in creatinine (2.3 to 2.5 mg/dl) compared to the non-coated group (1.8 to 2.3 mg/dl).
  • No patients in the HC group with preoperative creatinine clearance < 20 ml/min required postoperative dialysis.

Conclusions:

  • Heparin-coated circuits, combined with low-dose heparin, can preserve renal function post-cardiopulmonary bypass.
  • HC circuits are a viable option for managing patients with severe kidney disease undergoing cardiac procedures.