Related Experiment Videos
The causes and consequences of genetic variation in dengue virus
1Dept of Zoology, University of Oxford, South Parks Road, Oxford, UK. edward.holmes@zoo.ox.ac.uk
Trends in Microbiology
|February 9, 2000
Abstract:
Despite the fact that dengue is one of the most prevalent viral infections of humans, the mechanisms responsible for its pathogenesis remain uncertain. Evolutionary studies of dengue virus have revealed that its genetic diversity is increasing. This, coupled with evidence that viral strains could naturally differ in virulence, suggests that in the future we might be exposed to viruses with an expanded range of pathogenic properties.