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Updated: Aug 10, 2026

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome (ARDS)
Published on: April 7, 2021
Adult respiratory distress syndrome after extensive cytoreductive surgery. A case report
G H Eltabbakh1, C S Awtrey, P Walker
1Department of Obstetrics and Gynecology, University of Vermont, Burlington 05401, USA. gamal.eltabbakh@vtmednet.org
Background:
Adult respiratory distress syndrome (ARDS) is characterized by progressive hypoxemia, diffuse bilateral pulmonary infiltrates and normal left ventricular function.
Case:
A 58-year-old woman developed ARDS following extensive cytoreductive surgery for a widely disseminated intraperitoneal leiomyosarcoma. The patient had a favorable outcome after 10 days of ventilatory support, sedation, analgesia, parenteral and enteral nutrition, and fluid restriction. The ARDS might have been caused by multiple transfusions or the massive cytoreductive surgery and was probably mediated by cytokines and tumor necrosis factors.
Conclusion:
Gynecologic oncologists should be alert to postoperative ARDS in patients undergoing massive cytoreduction with excessive blood loss and multiple transfusions.
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