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Estimating plasma volume from red cell volume.

P S Cosgriff1, M Blunkett, O Morrish

  • 1Department of Medical Physics, Pilgrim Hospital, Boston, Lincs, UK. phil@phb-mpd.demon.co.uk

Nuclear Medicine Communications
|February 9, 2000
PubMed
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Estimating plasma volume using red cell volume and hematocrit is often inaccurate. Independent measurement of plasma volume is recommended for all patients due to significant discrepancies in estimations.

Area of Science:

  • Clinical Medicine
  • Biomedical Engineering

Background:

  • The withdrawal of licensed 125I-HSA in 1997 led to reliance on estimated plasma volume.
  • Current UK practice often estimates plasma volume using red cell volume and venous hematocrit.

Purpose of the Study:

  • To compare measured versus estimated plasma volume.
  • To assess the accuracy of plasma volume estimation in patients.

Main Methods:

  • Compared independently measured plasma volume with estimated plasma volume.
  • Analyzed data from 107 consecutive patients.

Main Results:

  • Estimated plasma volume was accurate to within +/- 5% in only 40% of patients.
  • Discrepancies exceeding +/- 10% were observed in 35% of cases.

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  • No reliable method exists to predict inaccurate estimations.

    • Conclusions:

    • Plasma volume estimation using red cell volume and hematocrit is unreliable.
    • Independent measurement of plasma volume is recommended for all patients.
    • Unlicensed 125I-HSA from reputable sources should be used for accurate measurement.