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Thyroid hormones regulate lipid metabolism in a teleost Anabas testudineus (Bloch)
1Department of Zoology, Endocrinology and Biochemistry Division, University of Kerala, India.
Abstract:
We compared the long-term action of 3,5,3'-triiodo-L-thyronine (T3) and 3,5-diiodo-L-thyronine (T2) on lipid metabolism in a teleost Anabas testudineus. Among the six groups of animals used in this experiment, except for the control group, all received 6-propylthiouracil (6-PTU) to create a hypothyroid state in order to analyse the action of iodothyronines on lipid metabolism. Injections of 6-PTU reduced T3 concentration in the circulation by 79.6% and injections of iodothyronines enhanced the level of T3 in the plasma, and a maximum increase was observed in T3 (500 ng)-treated specimens. Analysis of lipogenic enzymes in liver and heart showed that a tissue-specific variation exists in the action of thyroid hormones and, in many cases, activity is higher in T2-treated groups. Analysis of various lipid classes showed that long-term administration of T2 is also effective in producing a comparable effect with that of T3 on lipid metabolism.
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