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Crystallization and preliminary X-ray analysis of the thymidylate kinase from Mycobacterium tuberculosis
I Li de la Sierra1, H Munier-Lehmann, A M Gilles
1Unité de Biochimie Structurale, Institut Pasteur, 28 Rue du Dr Roux, 75724, Paris CEDEX 15, France.
Acta Crystallographica. Section D, Biological Crystallography
|February 10, 2000
Abstract:
Mycobacterium tuberculosis thymidylate kinase complexed with the substrate deoxythymidine monophosphate was crystallized in the hexagonal space group P6(5)22 or P6(1)22, with unit-cell parameters a = b = 76.62, c = 134.38 A and one single monomer of 23 kDa in the asymmetric unit. Cryo-cooled crystals diffract at 1.94 A resolution using synchrotron radiation.