Related Experiment Video
Updated: Aug 4, 2026

06:36
Nerve Stimulator-guided Injection of Autologous Stem Cells Near the Equine Left Recurrent Laryngeal Nerve
Published on: September 26, 2018
Syringohydromyelia in Cavalier King Charles spaniels
C Rusbridge1, J E MacSweeny, J V Davies
1Stone Lion Veterinary Center, London, England.
Journal of the American Animal Hospital Association
|February 10, 2000
Summary
Syringohydromyelia in Cavalier King Charles spaniels is linked to foramen magnum overcrowding and occipital bone malformations. Treatment with anti-inflammatory drugs showed partial improvement in clinical signs like scratching and pain.
Area of Science:
- Veterinary Neurology
- Comparative Pathology
Background:
- Syringohydromyelia is a condition characterized by fluid-filled cavities within the spinal cord.
- Foramen magnum overcrowding can lead to neurological deficits in dogs.
Purpose of the Study:
- To describe syringohydromyelia secondary to foramen magnum overcrowding in Cavalier King Charles spaniels.
- To correlate clinical signs with magnetic resonance imaging findings.
- To evaluate treatment outcomes.
Main Methods:
- Magnetic resonance imaging (MRI) was used to diagnose syringohydromyelia in seven Cavalier King Charles spaniels.
- Clinical signs were documented and analyzed.
- Dogs were treated with corticosteroids or nonsteroidal anti-inflammatory drugs.
Main Results:
- All seven dogs presented with clinical signs consistent with central spinal cord lesions.
- Common signs included persistent scratching, neck/limb pain, and lower motor neuron deficits.
- MRI revealed syringohydromyelia secondary to foramen magnum overcrowding, likely due to occipital bone malformation and cerebellar herniation.
Conclusions:
- Foramen magnum overcrowding and associated occipital bone malformations are implicated in the pathogenesis of syringohydromyelia in this breed.
- While anti-inflammatory treatment offered partial relief, complete resolution of clinical signs was not achieved.
Related Concept Videos
Multiple Sclerosis l: Introduction
Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
Herniated Intervertebral Disc l: Introduction
Intervertebral disc herniation refers to the displacement of the nucleus pulposus (the gel-like inner core of the disc) through a tear or weakened area in the annulus fibrosus (the outer fibrous ring). The displaced disc material extends beyond the normal boundaries of the disc space and may compress or irritate nearby spinal nerve roots or, less commonly, the spinal cord.Etiology and Risk FactorsHerniation commonly results from degeneration, in which aging reduces disc hydration and...
Cirrhosis I: Introduction
Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...

