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Effect of eating on plasma radical-trapping antioxidant activity (TRAP) in patients with cirrhosis
M Pirisi1, E Federico, N Bortolotti
1Dipartimento di Patologia e Medicina Sperimentale e Clinica, Università degli Studi, Udine, Italy. pirisi@dpmsc.uniud.it
Objectives:
To ascertain the effects of eating on plasma antioxidant capacity in patients with liver disease.
Design And Methods:
Eighteen cirrhotic patients were compared to 18 age and sex-matched controls. TRAP was measured by a fluorometric assay after a 12 h fast, and 60, 120, and 180 min after the study participants had taken a drink formula food.
Results:
In the fasting state, TRAP was higher in patients with alcoholic cirrhosis (847+/-39 micromol/L, mean +/- SEM) in comparison to patients with viral cirrhosis (653+/-41) and to controls (758+/-26) (p<0.005). In cirrhotic patients, TRAP did not change in the post-absorptive state. In controls, TRAP decreased progressively, to a value of 719+/-21 (p<0.02), and the AUC of the delta-values of TRAP and of plasma insulin showed an inverse correlation (r = -0.52, p<0.05).
Conclusions:
In normal subjects, but not in cirrhotics, TRAP decreases in the post-absorptive state, probably in relationship with the activation of metabolic pathways.
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