Focal nodular hyperplasia: natural course observed with CT and MRI
Related Experiment Videos
I Leconte1, B E Van Beers, M Lacrosse
1Department of Radiology, Université Catholique de Louvain, St. Luc University Hospital, Brussels, Belgium.
Purpose:
The purpose of this work was to assess the natural course of biopsy-proven focal nodular hyperplasia (FNH).
Method:
Eighteen biopsy-proven FNHs in 14 patients (12 women and 2 men) who were followed for at least 6 months with CT and/or MRI were included in the study. The volume of the lesions was calculated twice by two observers using the summation of areas method. Intra- and interobserver variability was assessed by intraclass correlation coefficients. Longitudinal data analysis was performed with generalized estimating equations.
Results:
The volume of FNH was stable in 6 cases, decreased in 10 cases, and increased in 2 cases. Intra- and interobserver variability in size measurements was 5-10%. Intraclass correlation coefficients were >0.992. Longitudinal data analysis showed that there was a general trend of lesion regression.
Conclusion:
Long-term follow-up and objective measurements performed in patients with biopsy-proven lesions show that the natural course of FNH is variable. In particular, lesion regression is not rare.