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Related Experiment Videos

Tardive dystonia.

P N van Harten1, R S Kahn

  • 1Psychiatric Center Zon & Schild, Amersfoort, The Netherlands. zonenschild.a-opl@wxs.nl

Schizophrenia Bulletin
|February 10, 2000
PubMed
Summary
This summary is machine-generated.

Tardive dystonia, a movement disorder from antipsychotics, affects 3% of patients. Treatment involves drug review, switching medications, or therapies like botulinum toxin for localized symptoms.

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Area of Science:

  • Neurology
  • Pharmacology

Background:

  • Tardive dystonia is an extrapyramidal syndrome linked to long-term dopamine receptor antagonist use.
  • It is characterized by sustained muscle contractions causing abnormal postures and repetitive movements.

Purpose of the Study:

  • To provide an overview of the phenomenology, epidemiology, and treatment of tardive dystonia.
  • To outline diagnostic criteria and identify risk factors for tardive dystonia.

Main Methods:

  • Review of existing literature on tardive dystonia.
  • Analysis of diagnostic criteria, including exclusion of other causes like Wilson's disease.
  • Examination of epidemiological data and identified risk factors.

Main Results:

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  • Tardive dystonia affects approximately 3% of patients on long-term antipsychotic treatment.
  • Risk factors include younger age, male sex, and co-existing tardive dyskinesia.
  • Treatment strategies depend on the severity and localization of dystonia.

    • Conclusions:

    • Management of tardive dystonia requires careful evaluation of causative antipsychotic medication.
    • Switching to atypical antipsychotics like clozapine can be beneficial.
    • Botulinum toxin and dopamine-depleting drugs are potential treatment options for extensive cases.