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[Neonatal hyperparathyroidism secondary to unknown maternal hypoparathyroidism]
P Daoud1, M Mirc, M F Tarazourte
1Service de pédiatrie et de réanimation infantile, CHI André-Grégoire, Montreuil, France.
Summary
Vitamin D analogues effectively treat maternal hypoparathyroidism, leading to healthy deliveries. Careful monitoring of calcium levels is crucial for managing potential neonatal complications like hyperparathyroidism.
Area of Science:
- Endocrinology
- Maternal-Fetal Medicine
- Neonatology
Context:
- Hypoparathyroidism during pregnancy poses risks to both mother and fetus.
- Untreated maternal hypoparathyroidism can lead to severe fetal complications.
- Vitamin D analogues are established treatments for hypoparathyroidism.
Purpose:
- To report a case of a neonate born to a mother with undiagnosed hypoparathyroidism.
- To highlight the management and outcomes of neonatal hypoparathyroidism.
- To evaluate the efficacy of 1 alpha-hydroxyvitamin D in this context.
Summary:
- A premature infant was born with severe demineralization and hypocalcemia due to undiagnosed maternal hypoparathyroidism.
- The neonate presented with significantly elevated parathyroid hormone (PTH) levels.
- Treatment with intravenous calcium, oral 1 alpha-hydroxyvitamin D, and mechanical ventilation normalized calcium levels and improved PTH.
- The infant experienced respiratory complications but showed good overall health by 20 months.
Impact:
- 1 alpha-hydroxyvitamin D is effective in managing neonatal hypoparathyroidism.
- Close monitoring of calcium and PTH levels is essential in infants of mothers with hypoparathyroidism.
- Early intervention can lead to favorable outcomes despite initial severity and prematurity.