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Related Experiment Videos

Progressive optic axon dystrophy and vacuslar changes in rd mice.

S Wang1, M P Villegas-Pérez, M Vidal-Sanz

  • 1Institute of Ophthalmology, University College London, United Kingdom.

Investigative Ophthalmology & Visual Science
|February 12, 2000
PubMed
Summary

Photoreceptor loss in rd mice causes retinal vascular changes and damage to retinal ganglion cells (RGCs) and their axons. These effects are similar to, but less severe than, those observed in Royal College of Surgeons (RCS) rats.

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Corrigendum to "Nerve fibre layer degeneration and retinal ganglion cell loss long term after optic nerve crush or transection in adult mice" [Exp Eye Res. (2018) 170:40-50. doi: 10.1016/j.exer.2018.02.010. Epub 2018 Feb 13].

Experimental eye research·2019

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Retinal Biology

Background:

  • Photoreceptor degeneration is a hallmark of several retinal diseases.
  • Vascular abnormalities in the retina can impact neuronal health.
  • The rd mouse and Royal College of Surgeons (RCS) rat are established models for studying retinal degeneration.

Purpose of the Study:

  • To investigate retinal vascular plexus changes in rd mice following photoreceptor loss.
  • To compare these vascular changes with those in RCS rats.
  • To determine if vascular pathology affects retinal ganglion cells (RGCs) and their axons in rd mice similarly to RCS rats.

Main Methods:

  • Retinal vascular patterns were analyzed using NADPH-diaphorase histochemistry and horseradish peroxidase (HRP) vessel filling.

Related Experiment Videos

  • Optic axons were visualized with RT97 antibody.
  • RGCs were labeled via retrograde transport of Fluorogold.

    • Main Results:

    • Rd mice developed vascular complexes at the outer retinal border, similar to RCS rats, but with different distribution.
    • Progressive axonal dystrophy was observed in the optic fiber layer of rd mice.
    • RGC loss in rd mice was broadly distributed and partly secondary to vascular-induced axonal dystrophy.

    Conclusions:

    • Photoreceptor loss in rd mice induces RGC axonal dystrophy and loss.
    • The milder RGC loss in rd mice compared to RCS rats may stem from early atrophy of the deep vascular plexus.
    • Vascular formations associated with photoreceptor degeneration contribute to RGC damage in rd mice.