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Experience with a Dutch kveim suspension in men and guinea pigs

R Kooy, E J Ruitenberg, J L Sirks

    Annals of the New York Academy of Sciences
    |January 1, 1976
    PubMed

    A Kveim antigen was prepared according to the Chase-Siltzbach method from the spleen of a patient with sarcoidosis. This antigen was tested in a number of patients with sarcoidosis or possible sarcoidosis and also in a number of non-sarcoid patients. Several lots prepared from this spleen were compared, yielding differences in reactogenicity. Maybe this can be explained by heterogeneity of the spleen. An animal model (the BCG-presensitized guinea pig) is presented that may be applicable for a preclinical evaluation of lots of Kveim antigen.

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