Related Experiment Video
Updated: Oct 17, 2026
A Translational Surgical Porcine Model for Postoperative Intra-Abdominal Adhesion Formation
Published on: March 13, 2026
Fibrin glue reduces the severity of intra-abdominal adhesions in a rat model
C de Virgilio1, M Elbassir, A Hidalgo
1Department of Surgery, Harbor-UCLA Medical Center, Torrance, California 90509, USA.
Background:
The purpose of this study was to determine whether fibrin glue inhibits intra-abdominal adhesions.
Methods:
Twenty rats underwent midline laparotomy. To maximize adhesions, bilateral peritoneal muscular defects were created and covered with polypropylene mesh sewn with a braided suture. The bowel was abraded with dry gauze. Rats were randomized to either fibrin glue (FG) sprayed over the mesh or to control (no further treatment) groups. At 1 week, the adhesion density (graded 0 to 3), the percentage of the patch covered by adhesion (0% to 100%), and adhesion type were recorded.
Results:
The mean adhesion density was 1.45+/-0.33 for FG versus 2.8+/-0.11 for controls (P = 0.001). The mean percentage of adhesions was 36+/-9.9 for the FG group and 94+/-3.7 for controls (P = 0.0002). Bowel or solid organs were adherent to the patch in 6 of 20 (30%) in the FG group versus 12 of 20 (70%) in controls (P = 0.057).
Conclusions:
Topical fibrin glue reduces the density and severity of intra-abdominal adhesions in a rat model.
