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[Usefulness of conditioned place preference (CPP) paradigm and its practical application].

T Suzuki1

  • 1Department of Toxicology, School of Pharmacy, Hoshi University, Tokyo, Japan.

Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica
|February 15, 2000
PubMed
Summary

The conditioned place preference (CPP) paradigm, a key method for assessing drug effects, is now established in mice. This behavioral approach aids in understanding reward mechanisms and screening for drug abuse liability.

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Area of Science:

  • Behavioral neuroscience
  • Pharmacology
  • Neuroscience

Context:

  • The conditioned place preference (CPP) paradigm is a widely used behavioral method for evaluating the rewarding and aversive properties of drugs.
  • It was developed to overcome limitations of traditional drug self-administration techniques.
  • CPP has become the predominant method for assessing drug reward, surpassing self-administration in reported studies.

Purpose:

  • To review the significance, methodology, applications, and controversies surrounding the CPP paradigm.
  • To highlight the successful establishment of the CPP paradigm in mice, expanding its utility.
  • To underscore CPP's role in elucidating neural mechanisms of reward and screening for drug abuse potential.

Summary:

  • This review focuses on the conditioned place preference (CPP) paradigm, a crucial tool in pharmacology and neuroscience.

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  • It details the paradigm's evolution, its advantages over self-administration, and its successful adaptation for mouse models.
  • The review covers the methodology, applications, and ongoing debates concerning CPP's interpretation.

    • Impact:

    • The establishment of CPP in mice broadens its applicability for preclinical research on drug effects.
    • CPP serves as a vital behavioral assay for investigating the neural underpinnings of reward.
    • This paradigm is instrumental in screening potential therapeutic agents and identifying drugs with abuse liability.