Psychiatric genetics: back to the future

Area of Science:

• Neuroscience
• Genetics
• Psychiatry

Background:

• Geneticists predicted molecular genetics would revolutionize psychiatric disorder and behavior understanding.
• These expectations have largely remained unfulfilled over the past decade.
• The completion of the human genome sequence prompts a re-evaluation of the field.

Purpose of the Study:

• To assess the current state of molecular genetics in understanding psychiatric disorders.
• To identify challenges and necessary resources for future advancements.
• To contemplate the trajectory of the field as the human genome sequence nears completion.

Main Methods:

• Review of existing literature and predictions in molecular genetics.
• Analysis of the impact of genetic research on psychiatric understanding.
• Prospective evaluation of future research directions and resource allocation.

Main Results:

• Despite significant advancements in molecular genetics, a revolution in understanding psychiatric disorders has not materialized.
• Few exceptions exist where genetic insights have significantly impacted psychiatric research.
• The field faces challenges in translating genetic discoveries into clinical applications for psychiatric conditions.

Conclusions:

• The anticipated revolution in psychiatric understanding through molecular genetics has been slower than predicted.
• Continued focus on challenges and resource allocation is crucial for future progress.
• Re-evaluation of the field's state is timely given the nearing completion of the human genome sequence.