Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Strategic processing and episodic memory impairment in obsessive compulsive disorder.

C R Savage1, T Deckersbach, S Wilhelm

  • 1Department of Psychiatry, Massachusetts General Hospital, Charlestown 02129-2060, USA. savage@psych.mgh.harvard.edu

Neuropsychology
|February 16, 2000
PubMed
Summary

Obsessive compulsive disorder (OCD) patients show impaired verbal and nonverbal memory due to poor organizational strategies. These memory deficits are linked to frontal-striatal system dysfunction.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corrigendum to "Randomized, proof-of-concept trial of low dose naltrexone for patients with breakthrough symptoms of major depressive disorder on antidepressants" [J. Affect. Disord. 208 (2017, Jan. 15) 6-14, doi: 10.1016/j.jad.2016.08.029, Epub 2016 Oct. 1].

Journal of affective disorders·2017
Same author

The obese brain as a heritable phenotype: a combined morphometry and twin study.

International journal of obesity (2005)·2016
Same author

Meta-analysis of association between obsessive-compulsive disorder and the 3' region of neuronal glutamate transporter gene SLC1A1.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics·2013
Same author

Genome-wide association study of obsessive-compulsive disorder.

Molecular psychiatry·2012
Same author

A screening and prevention programme serving an ethnically diverse population of women at high risk of developing breast and/or ovarian cancer.

Ecancermedicalscience·2012
Same author

Importance of reward and prefrontal circuitry in hunger and satiety: Prader-Willi syndrome vs simple obesity.

International journal of obesity (2005)·2011

Area of Science:

  • Neuroscience
  • Psychology
  • Cognitive Science

Background:

  • Nonverbal memory deficits in obsessive compulsive disorder (OCD) may stem from impaired strategic processing.
  • Previous studies on verbal memory in OCD have not adequately assessed organizational strategies.

Purpose of the Study:

  • To investigate verbal and nonverbal memory performance in OCD patients, focusing on organizational strategies.
  • To determine if memory deficits in OCD are mediated by strategic processing impairments.

Main Methods:

  • Utilized the Rey-Osterrieth Complex Figure Test for nonverbal memory and the California Verbal Learning Test for verbal memory.
  • Compared performance of 33 OCD patients against 30 healthy control participants.
  • Employed multiple regression modeling to analyze the relationship between strategic processing and memory recall.

Related Experiment Videos

Main Results:

  • OCD patients demonstrated significant impairments in both verbal and nonverbal measures of organizational strategy and free recall.
  • Multiple regression analysis confirmed that impaired organizational strategies mediated free recall difficulties in OCD patients.
  • Findings suggest strategic processing deficits underlie episodic memory impairments in OCD.

Conclusions:

  • Verbal and nonverbal episodic memory deficits in OCD are significantly influenced by impaired strategic processing.
  • Results support neurobiological models implicating frontal-striatal system dysfunction in OCD.
  • The study highlights the importance of assessing strategic processing in understanding memory impairments in OCD.