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Stain, plaque and gingivitis reduction by combining chlorhexidine and peroxyborate
L J Gründemann1, M F Timmerman, Y Ijzerman
1Department of Periodontology, ACTA, The Netherlands.
Journal of Clinical Periodontology
|February 16, 2000
Summary
Adding an oxidizing agent to chlorhexidine mouthwash significantly reduced plaque, gingivitis, and staining compared to chlorhexidine alone. This combination therapy offers superior oral hygiene benefits.
Area of Science:
- Oral Hygiene
- Periodontology
- Preventive Dentistry
Background:
- Previous research indicates that combining oxidizing agents with chlorhexidine can decrease tooth staining.
- Chlorhexidine is a widely used antimicrobial agent for oral hygiene but can cause staining.
Purpose of the Study:
- To evaluate the efficacy of an oxidizing mouthrinse as an adjunct to chlorhexidine in reducing stain, plaque, and gingivitis.
- To compare the outcomes of chlorhexidine alone versus chlorhexidine combined with an oxidizing agent.
Main Methods:
- A 14-day, single-blind, two-group parallel study was conducted.
- Participants (n=28) were randomly assigned to use either chlorhexidine (CHX) alone or CHX with an oxidizing agent (sodium perborate-monohydrate).
- Evaluations included plaque levels, gingival bleeding (bleeding on marginal probing), and staining (gingival modification of the stain index) at baseline and after 14 days.
Main Results:
- The combination group (CHX+PER) showed significantly lower plaque scores (0.08 vs. 0.18, p=0.03) and gingival bleeding (0.21 vs. 0.38, p<0.001) compared to the CHX-only group.
- The proportion of stained surfaces was significantly reduced in the CHX+PER group (28%) compared to the CHX group (48%, p=0.04).
Conclusions:
- The adjunctive use of an oxidizing agent (sodium perborate-monohydrate) with chlorhexidine is superior to chlorhexidine alone in inhibiting plaque and gingivitis.
- Combining chlorhexidine with an oxidizing mouthrinse effectively reduces tooth staining.