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Published on: January 21, 2020
Systemic Lipidomics Identifies Altered Ceramide-Phospholipid Balance Associated With Periodontitis Severity: A
Minja Tuomivaara1, Anne-Mari Halme2, Muhammed Manzoor1,2
1School of Medicine, Institute of Dentistry, University of Eastern Finland, Kuopio, Finland.
Journal of Clinical Periodontology
|August 3, 2026
Summary
Periodontitis severity correlates with altered systemic ceramide and phospholipid profiles, especially ceramide:phosphocholine ratios. However, baseline lipid levels do not predict future periodontitis progression, suggesting inflammation mediates these links.
Area of Science:
- Lipidomics
- Periodontology
- Cardiovascular Health
Background:
- Periodontitis is a prevalent inflammatory condition affecting oral health.
- Systemic inflammation associated with periodontitis may influence lipid metabolism.
- Understanding the interplay between periodontitis and lipid profiles is crucial for comprehensive health assessment.
Purpose of the Study:
- To determine if periodontitis stage and grade correlate with circulating active lipid mediators.
- To investigate if baseline lipid species predict the progression of periodontitis.
- To explore the mediating role of systemic inflammation in the relationship between periodontitis and lipid profiles.
Main Methods:
- Analysis of plasma ceramides (Cer) and phosphocholines (PC) using LC-MS/MS in 473 Finnish participants.
- Clinical and radiographic assessment of periodontal status.
- 12-year follow-up data for 117 individuals to assess periodontitis progression.
Main Results:
- Increased ceramide:ceramide and ceramide:phosphocholine ratios were observed with higher periodontitis stage, grade, and edentulousness.
- Specific ceramide and phosphocholine species and ratios were significantly associated with periodontal measures.
- Baseline lipid levels did not predict periodontitis progression over 12 years.
Conclusions:
- Periodontitis severity is linked to systemic alterations in ceramide and phospholipid profiles.
- Systemic inflammation appears to mediate the association between periodontitis and circulating lipid species.
- The study highlights disturbances in lipidomic homeostasis related to periodontitis.
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