Related Experiment Video
Updated: Jun 6, 2026
07:15
Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
Periodontitis and Endotoxemia: Clinical and Microbiological Insights
Anbo Dong1, Muhammed Manzoor2,3, Jaakko Leskelä2
1Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, UK.
Journal of Clinical Periodontology
|June 4, 2026
Summary
Periodontitis elevates lipopolysaccharide (LPS) activity in both the mouth and blood, linking oral health to systemic endotoxemia. Fretibacterium bacteria significantly contribute to this LPS translocation.
Area of Science:
- Oral microbiology
- Periodontology
- Systemic health
Background:
- Periodontitis is linked to systemic diseases, potentially via lipopolysaccharide (LPS) translocation.
- Investigating LPS activity in subgingival plaque and serum is crucial for understanding this link.
Purpose of the Study:
- To assess subgingival and serum LPS activity in periodontitis and gingivitis patients.
- To correlate LPS activity with periodontal parameters and microbial profiles.
- To identify bacterial contributors to LPS translocation.
Main Methods:
- Analysis of LPS activity using recombinant Factor C assay in 270 participants.
- 16S rRNA sequencing for subgingival microbiota profiling.
- Multivariate regressions and MaAsLin2 for taxonomic and functional pathway analysis.
Main Results:
- Periodontitis patients showed significantly higher serum and subgingival LPS activity.
- Serum LPS activity correlated with subgingival microbial dysbiosis index (SMDI).
- Fretibacterium was identified as a key contributor to both subgingival and serum LPS.
Conclusions:
- Elevated serum LPS is linked to periodontitis and subgingival dysbiosis.
- The periodontal niche is a source of systemic endotoxemia.
- Fretibacterium plays a significant role in LPS translocation and systemic effects.
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