Hereditary epidermolysis bullosa: oral manifestations and dental therapy

The oral and dental manifestations of epidermolysis bullosa hereditaria were evaluated in seventeen patients with this disorder. Clinical findings were correlated with the electron microscope--documented diagnosis of each variant of epidermolysis bullosa hereditaria. Significant differences in the dental and oral presentations of each variant indicate the importance of considering these findings in differential diagnosis of the variants and in treatment planning for dental disease in these patients. A rationale for surgical and restorative intervention based on experience with these seventeen patients is presented.