Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The p38 signal transduction pathway: activation and function.

K Ono1, J Han

  • 1Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA.

Cellular Signalling
|February 17, 2000
PubMed
Summary

The p38 signalling pathway, a type of Mitogen-activated protein (MAP) kinase, regulates crucial cellular functions like inflammation and cell death. This review details its components, targets, and physiological roles in cellular responses.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Inductively-coupled control unit for fully implantable middle ear hearing devices.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference·2007
Same author

Extensive nuclear localization of alpha-synuclein in normal rat brain neurons revealed by a novel monoclonal antibody.

Neuroscience·2007
Same author

Fine needle aspiration cytology of solitary fibrous tumours of the pleura.

Cytopathology : official journal of the British Society for Clinical Cytology·2007
Same author

Creutzfeldt-Jakob disease in a Chinese patient with a novel seven extra-repeat insertion in PRNP.

Journal of neurology, neurosurgery, and psychiatry·2007
Same author

Endoscopic removal of biliary self-expandable metallic stents: a prospective study.

Endoscopy·2006
Same author

Interaction between GNB3 C825T and ACE I/D polymorphisms in essential hypertension in Koreans.

Journal of human hypertension·2006

Area of Science:

  • Cellular Biology
  • Molecular Biology
  • Biochemistry

Background:

  • The p38 signalling pathway is a Mitogen-activated protein (MAP) kinase pathway.
  • It is integral to cellular processes including inflammation, differentiation, growth, and death.

Purpose of the Study:

  • To review the major components of the p38 signalling pathway.
  • To highlight the pathway's targets and the physiological functions of p38 activation.

Main Methods:

  • Literature review of existing research on the p38 signalling pathway.
  • Analysis of studies detailing pathway components, activation mechanisms, and cellular responses.

Main Results:

  • p38 activation, often triggered by extracellular stimuli like pathogens and cytokines, mediates signal transduction to the nucleus.

Related Experiment Videos

  • The pathway regulates gene expression and influences various cellular components to execute specific responses.

    • Conclusions:

    • The p38 pathway is a critical regulator of cellular processes.
    • Understanding its components and targets is key to comprehending its physiological functions and roles in cellular responses.