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Effects of allitridi on intracellular Ca2+ concentration in isolated rat brain cells
Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica
|May 16, 2000
Abstract
Aim:
To study actions of allitridi extracted from garlic on intracellular calcium in isolated rat brain cells.
Methods:
Brain cells were isolated from newborn rat brain with Fura 2-AM measurements of intracellular Ca2+ concentration ([Ca2+]i).
Results:
Allitridi 1-100 mumol.L-1 concentration-dependently blocked increases of [Ca2+]i caused by potassium chloride and sodium glutamate (Glu) with IC50 of 59.7 and 69.9 mumol.L-1 respectively. Allitridi 100 mumol.L-1 blocked norepinephrine (Nor)-induced [Ca2+]i elevation.
Conclusion:
Allitridi is an effective agent for blocking the [Ca2+]i increase caused by potassium chloride, Nor and Glu.