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Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death
09:18

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death

Published on: December 27, 2016

Action of Myc in vivo - proliferation and apoptosis

S Pelengaris1, B Rudolph, T Littlewood

  • 1Biological Sciences, University of Warwick, Coventry, CV4 7AL, UK. cjpy@dna.bio.warwick.ac.uk.

Current Opinion in Genetics & Development
|February 19, 2000
PubMed

Insights

Oncogenes like Myc can drive cell growth and death. The balance between these processes is key to tumor development and persistence, as shown in new mouse studies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Dominant oncogenes encode proteins that regulate cell proliferation and apoptosis.
  • Dysregulation of these processes is a hallmark of cancer.
  • The balance between oncogene-driven proliferation and apoptosis is critical in tumorigenesis.

Purpose of the Study:

  • To investigate the role of the proliferation-apoptosis balance in Myc-induced carcinogenesis.
  • To understand how this balance influences tumor initiation and maintenance.

Main Methods:

  • Utilizing transgenic mouse models.
  • Employing an ectopically regulatable Myc gene or protein.
  • Analyzing the interplay between Myc expression, cell proliferation, and apoptosis.

Main Results:

  • Demonstrated that the balance between oncogene-induced proliferation and apoptosis is a critical determinant in tumor development.
  • Highlighted the significance of this balance in both the initiation and maintenance phases of carcinogenesis.
  • Provided insights into Myc's role in cancer through its influence on cell fate.

Conclusions:

  • The balance between cell proliferation and apoptosis is a crucial factor in Myc-induced cancer.
  • Modulating this balance could be a therapeutic strategy for cancer treatment.
  • Further research in this area is warranted to fully elucidate oncogene-driven tumorigenesis.

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