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Related Experiment Videos

Rational antigen modification as a strategy to upregulate or downregulate antigen recognition.

S I Abrams1, J Schlom

  • 1Laboratory of Tumor Immunology and Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1750, USA. sa47z@nih.gov

Current Opinion in Immunology
|February 19, 2000
PubMed
Summary
This summary is machine-generated.

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Scientists can now rationally modify T-cell recognition sites to control immune responses. This allows for boosting immunity against infections and cancers, or dampening it in autoimmune diseases.

Area of Science:

  • Immunology
  • Molecular Biology
  • Biomedical Science

Background:

  • Recent advances illuminate T-cell antigen recognition mechanisms.
  • Understanding CD8(+) and CD4(+) T lymphocyte interactions is key.

Purpose of the Study:

  • To explore rational modification of antigenic determinants.
  • To investigate therapeutic applications in disease regulation.

Main Methods:

  • Focus on cellular and molecular mechanisms of T-cell antigen recognition.
  • Experimental manipulation of peptide ligand properties.

Main Results:

  • Possibilities for site-directed modification of antigenic determinants.
  • Potential for regulating host immunity against diverse diseases.

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Conclusions:

  • Agonistic peptides can upregulate T-cell responses for infectious and neoplastic diseases.
  • Antagonistic peptides can downregulate T-cell responses in autoimmunity.
  • Peptide manipulation offers preventive and therapeutic clinical potential.