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Identification of HLA-class-II-restricted epitopes of autoantigens in transgenic mice
1Department of Immunology, Mayo Medical School, Rochester, MN-55905, USA. abraham.roshini@mayo.edu
Current Opinion in Immunology
|February 19, 2000
Abstract:
The past year has seen a spate of research in the use of HLA transgenic mice in the identification of self antigens associated with autoimmunity. Dominant T cell determinants - and, in a few cases, B cell determinants - have been characterized in the context of disease-predisposing HLA DR and DQ genes for at least three prominent and devastating autoimmune diseases: rheumatoid arthritis, multiple sclerosis and insulin-dependent diabetes mellitus.