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Squamous cell carcinoma of maxillary sinus
R Tiwari1, J A Hardillo, D Mehta
1Department of Otolaryngology, Head Neck Surgery, Section of Surgical Oncology, Reconstructive and Skull Base Surgery, University Hospital VU, De Boelelaan 1117, Postbus 7057, 1007 MB Amsterdam, The Netherlands.
Head & Neck
|February 19, 2000
Summary
Late diagnosis of squamous cell carcinoma is common. Surgery with postoperative radiotherapy is the preferred treatment, offering a 64% five-year survival rate for head and neck cancer patients.
Area of Science:
- Otolaryngology
- Head and Neck Surgery
- Oncology
Background:
- Retrospective analysis of 43 patients diagnosed with squamous cell carcinoma between 1975 and 1994.
- Patients treated at the VU Amsterdam Otolaryngology Head and Neck Surgery department.
Purpose of the Study:
- To evaluate treatment outcomes and survival rates for squamous cell carcinoma.
- To identify optimal treatment strategies for advanced head and neck cancers.
Main Methods:
- Tumors restaged using the 1997 UICC classification.
- Treatment modalities included surgery with postoperative radiotherapy, chemotherapy followed by radiotherapy, and curative treatment.
- Survival data analyzed with no loss to follow-up.
Main Results:
- 83% of tumors presented at Stage III or IV.
- Overall five-year survival was 64%; stage-specific survival rates were 83% (Stage II), 49% (Stage III), and 37% (Stage IV).
- Two-year survival after chemotherapy and radiotherapy was 37%; 4.1% presented with cervical nodal metastases.
Conclusions:
- Squamous cell carcinoma is frequently diagnosed at late stages.
- Surgery followed by radiotherapy is the treatment of choice for head and neck squamous cell carcinoma.
- Mandibulotomy may improve retromaxillary space clearance in T3-T4 tumors; eye preservation is recommended when oncologically feasible.