Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Nitrogen oxide inhalation in critically ill patients].

J Bonde1, K Antonsen, S W Henneberg

  • 1Anaestesiologisk afdeling, Amtssygehuset i Herlev.

Ugeskrift for Laeger
|February 19, 2000
PubMed
Summary

Inhaled nitric oxide (iNO) improves oxygenation and reduces pulmonary hypertension but does not decrease mortality in severe respiratory failure. In neonates, iNO may reduce the need for extracorporeal membrane oxygenation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Brief History of the Discovery of Amelogenin Nanoribbons In Vitro and In Vivo.

Journal of dental research·2021
Same author

Clinical performance of the HPV-Risk assay on cervical samples in SurePath medium using the VALGENT-4 panel.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology·2019
Same author

VALHUDES: A protocol for validation of human papillomavirus assays and collection devices for HPV testing on self-samples and urine samples.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology·2018
Same author

Not all HPV nucleic acid tests are equal: only those calibrated to detect high grade lesions matter for cervical screening: Response to 'Concordant testing results between various human papillomavirus assays in primary cervical cancer screening: systematic review' by de Thurah, Bonde, Uyen, Lam and Rebolj. Published 27 May, 2017.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2017
Same author

High-grade cervical intraepithelial neoplasia in human papillomavirus self-sampling of screening non-attenders.

British journal of cancer·2017
Same author

Referral population studies underestimate differences between human papillomavirus assays in primary cervical screening.

Cytopathology : official journal of the British Society for Clinical Cytology·2017

Area of Science:

  • Critical care medicine
  • Pulmonology
  • Neonatology

Context:

  • Inhaled nitric oxide (iNO) is a widely adopted therapy for severe hypoxemic respiratory failure and pulmonary hypertension.
  • Clinical evidence consistently shows iNO improves oxygenation and lowers pulmonary artery pressures.

Purpose:

  • To evaluate the efficacy of iNO in reducing mortality in patients with severe respiratory failure.
  • To assess the impact of iNO on the need for extracorporeal membrane oxygenation (ECMO) in neonates.

Summary:

  • Randomized trials have not demonstrated a mortality benefit of iNO in adult patients with severe respiratory failure.
  • iNO can decrease the requirement for ECMO in neonates suffering from severe respiratory failure and pulmonary hypertension.
  • Non-pharmacological interventions like optimizing ventilator settings and prone positioning should be considered before initiating iNO in adults.

Related Experiment Videos

Impact:

  • Highlights the nuanced role of iNO, emphasizing its benefits in specific populations (neonates) and clinical outcomes (oxygenation, ECMO reduction) while questioning its mortality benefit in adults.
  • Suggests a stepwise approach to managing severe respiratory failure, prioritizing conventional therapies before considering iNO for adult patients.
  • Informs clinical decision-making regarding the use of inhaled nitric oxide in critical care settings.