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Updated: Oct 17, 2026
Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis
Published on: March 9, 2018
Efficacy of SCH56592 in a rabbit model of invasive aspergillosis
W R Kirkpatrick1, R K McAtee, A W Fothergill
1Departments of Medicine, San Antonio, Texas 78284, USA. KIRKPATRICK@UTHSCSA.EDU
Abstract:
SCH56592 (SCH) was evaluated in an immunosuppressed rabbit model of invasive aspergillosis. SCH was more effective than similar doses of itraconazole and as effective as amphotericin B in the clearance of Aspergillus spp. from tissues. Compared with controls, SCH regimens reduced mortality, improved survival, and significantly reduced tissue colony counts.
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